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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
21/01/2020 |
Actualizado : |
21/01/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
DE CARVALHO NUNES, L.; STEGELMEIER, B. L.; COOK, D.; PFISTER, J. A.; GARDNER, D. R.; RIET-CORREA, F.; WEICH, K. D. |
Afiliación : |
LOUISIANE DE CARVALHO NUNES, Department of Veterinary Science, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil; BRYAN L. STEGELMEIER, USDA-ARS Poisonous Plant Research Laboratory, USA; DANIEL COOK, USDA-ARS Poisonous Plant Research Laboratory, USA; JAMES A. PFISTER, USDA-ARS Poisonous Plant Research Laboratory, USA; DALE R. GARDNER, USDA-ARS Poisonous Plant Research Laboratory, USA; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Veterinary Hospital, Center for Health and Rural Technology, Patos Campus, Federal University of Campina Grande, Brazil; KEVIN D. WELCH, USDA-ARS Poisonous Plant Research Laboratory, USA. |
Título : |
Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats. |
Fecha de publicación : |
2019 |
Fuente / Imprenta : |
Toxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016 |
ISSN : |
0041-0101 |
DOI : |
10.1016/j.toxicon.2019.09.016 |
Idioma : |
Inglés |
Notas : |
Article history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. |
Contenido : |
ABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine.
© 2019 MenosABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic a... Presentar Todo |
Palabras claves : |
Astragalus; Calystegines; Ipomoea; Locoweed; PLATAFORMA SALUD ANIMAL; Swainsonine. |
Asunto categoría : |
A50 Investigación agraria |
Marc : |
LEADER 02878naa a2200301 a 4500 001 1060655 005 2020-01-21 008 2019 bl uuuu u00u1 u #d 022 $a0041-0101 024 7 $a10.1016/j.toxicon.2019.09.016$2DOI 100 1 $aDE CARVALHO NUNES, L. 245 $aClinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.$h[electronic resource] 260 $c2019 500 $aArticle history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. 520 $aABSTRACT. The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine. © 2019 653 $aAstragalus 653 $aCalystegines 653 $aIpomoea 653 $aLocoweed 653 $aPLATAFORMA SALUD ANIMAL 653 $aSwainsonine 700 1 $aSTEGELMEIER, B. L. 700 1 $aCOOK, D. 700 1 $aPFISTER, J. A. 700 1 $aGARDNER, D. R. 700 1 $aRIET-CORREA, F. 700 1 $aWEICH, K. D. 773 $tToxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016
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25. | | RABAZA, A.; FRAGA, M.; REPETTO, J.; CAJARVILLE, C.; PLA, M.; BANCHERO, G. Acidosis ruminal subaguda en novillos de engorde: uso de haptoglobina para evaluar respuesta inflamatoria causada por el ayuno y realimentación. In: Jornadas Uruguayas de Buiatría, 44., 2016, Paysandú, UY.; Gianneechini, E.; Elizondo, V. (Ed.).Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2016. p.163-165Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA La Estanzuela. |
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28. | | CAJARVILLE, C.; BRITOS, A.; ERRANDONEA, N.; GUTIÉRREZ, L.; COZZOLINO, D.; REPETTO, J.L. Diurnal changes in water-soluble carbohydrate concentration in lucerne and tall fescue in autumn and the effects on in vitro fermentation. Research Article. New Zealand Journal of Agricultural Research, 2015, v. 58, no.3, p. 281-291. Article history: Received 23 January 2014 // Accepted 5 February 2015.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Las Brujas. |
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30. | | CAPELESSO, A.; DAYUTO, J.; KOZLOSKI, G.; MENDOZA, A.; REPETTO, J.; CAJARVILLE, C. Efecto de la caminata y del tiempo de ayuno sobre el pH ruminal de vacas lecheras en pastoreo. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 210-212.Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA La Estanzuela. |
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31. | | BASANTES, S.; CAJARVILLE, C.; MORALES, T.; PLA, M.; NOBLE, C.; PÉREZ, G.; ZUNINO, E.; MENDOZA, A. Efecto del nivel de alimentación preparto sobre la producción y composición de leche de vacas a pastoreo. In JORNADAS URUGUAYAS DE BUIATRÍA, 42., 2014, Paysandú, UY; ELIZONDO, V.; MATTO, C. (Ed.). [Trabajos presentados]: posters. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2014. p. 233-235.Biblioteca(s): INIA La Estanzuela. |
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32. | | BASANTE, S.; CAJARVILLE, C.; MORALES-PIÑEYRUA, J.; PLA, M.; ÁLVAREZ, C.; BERNEDA, E.; MENDOZA, A. Efecto del nivel de alimentación preparto sobre el reinicio de la actividad luteal posparto en vacas lecheras.[Effect of prepartum feeding level on the onset of postpartum luteal activity in dairy cows]. RF 7. In: Congreso Argentino de Producción Animal, 38., 2015. Resúmenes. Santa Rosa, La Pampa, AR: ASAS/AAPA, 2015. p.7. (Revista Argentina de Producción Animal; 2015; 35; supl.1).Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA La Estanzuela. |
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33. | | RABAZA, A.; REPETTO, J.; CAJARVILLE, C.; FRAGA, M.; PLA, M.; BANCHERO, G. Efecto de la presencia y severidad del ayuno sobre la aparición de acidosis subaguda en novillos bajo el sistema de engorde a corral. [Resumen]. Congreso de la Asociación Latinoamericana de Producción Animal, 24.; Congreso de la Sociedad Chilena de Producción Animal, 40., Puerto Varas, Chile, 9 al 13 noviembre 2015. ln: Reunión ALPA (24., Puerto Varas, Chile). Resúmenes. Puerto Varas (Chile): ALPA, 2015. p. 981.Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA La Estanzuela. |
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34. | | SANTANA, A.; DAYUTO , J; CONSTANTIN, M; MENDOZA, A.; REPETTO, J.; CAJARVILLE, C. El fraccionamiento de 8 horas de pastoreo de alfalfa en dos sesiones aumenta el contenido de ácidos grasos trans de la leche. [Resumen]. En: CONGRESO ASOCIACIÓN URUGUAYA DE PRODUCCIÓN ANIMAL (6º, Marzo, 2018, Tacuarembó, Uruguay). Tacuarembó: AUPA, 2018. p. 24.Tipo: Abstracts/Resúmenes |
Biblioteca(s): INIA La Estanzuela. |
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35. | | MENDOZA, A.; CAJARVILLE, C.; BRAMBILLASCA, S.; ROSAS, F.; IRIARTE, E.; REPETTO, J.L. Evaluación in vitro de la actividad del líquido ruminal de vacas alimentadas con forraje fresco y ración totalmente mezclada. In: JORNADAS URUGUAYAS DE BUIATRÍA, 41, 2013, Paysandú, Uruguay. Posters. Paysandú, UY: Centro Médico Veterinario de Paysandú, SUB, SMVU. 2013. p.148-149.Biblioteca(s): INIA La Estanzuela. |
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36. | | FRAGA, M.; PERELMUTER, K.; VALENCIA, M.J.; MARTÍNEZ, M.; ABIN-CARRIQUIRY, A.; CAJARVILLE, C.; ZUNINO, P. Evaluation of native potential probiotic bacteria using an in vitro ruminal fermentation system. Annals of Microbiology, September 2014, Volume 64, Issue 3, pp 1149-1156. Article history:Received: 11 July 2013 /Accepted: 29 October 2013.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : B - 1 |
Biblioteca(s): INIA La Estanzuela. |
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37. | | CAPELESSO, A.; MENDOZA, A.; KOZLOSKI, G.; CAJARVILLE, C.; DAYUTO, J.; REPETTO, J. Extra walking of dairy cows to access the pasture in a grazing system: Effect on feeding behaviour. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.21-23. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1)Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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38. | | CAPELESSO, A.; MENDOZA, A.; KOZLOSKI, G.; CAJARVILLE, C.; DAYUTO, J.; REPETTO, J. Extra walking of dairy cows to access the pasture in a grazing system: Effect on intake and digestibility. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.24-25. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1)Tipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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39. | | STIRLING, S.; DIAZ-LAGO, J.E.; REPETTO, J.; PLA, M.; ARROYO, J.; CAJARVILLE, C. Growth stage and ensiling: impact on chemical composition, conservation quality and in situ ruminal degradability of whole-crop oat. Journal of the Science of Food and Agriculture. 2021, Volume102, Issue 7, pages 2783-2791. doi: https://doi.org/10.1002/jsfa.11619 Article history: Received 5 March 2021; Revised 2 October 2021; Accepted article published 29 October 2021. -- Corresponding author: Cajarville, C.; Departamento de Producción Animal y Salud de Sistemas Productivos (IPAV),...Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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40. | | RABAZA, A.; BANCHERO, G.; CAJARVILLE,C.; ZUNINO, P.; BRITO, A.; REPETTO, J.; FRAGA, M. Effects of feed withdrawal duration on animal behaviour, rumen microbiota and blood chemistry in feedlot cattle: implications for rumen acidosis. Animal, Volume 14 , Issue 1 , January 2020 , pp. 66 - 77. DOI: https://doi.org/10.1017/S1751731119001538 Article history: Received 22 October 2018 // Accepted 13 June 2019.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA La Estanzuela. |
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